[HTML][HTML] Contribution of human thrombospondin-1 to the pathogenesis of gram-positive bacteria
U Binsker, TP Kohler, S Hammerschmidt - Journal of Innate Immunity, 2019 - karger.com
U Binsker, TP Kohler, S Hammerschmidt
Journal of Innate Immunity, 2019•karger.comA successful colonization of different compartments of the human host requires multifactorial
contacts between bacterial surface proteins and host factors. Extracellular matrix proteins
and matricellular proteins such as thrombospondin-1 play a pivotal role as adhesive
substrates to ensure a strong interaction with pathobionts like the Gram-positive
Streptococcus pneumoniae and Staphylococcus aureus. The human glycoprotein
thrombospondin-1 is a component of the extracellular matrix and is highly abundant in the …
contacts between bacterial surface proteins and host factors. Extracellular matrix proteins
and matricellular proteins such as thrombospondin-1 play a pivotal role as adhesive
substrates to ensure a strong interaction with pathobionts like the Gram-positive
Streptococcus pneumoniae and Staphylococcus aureus. The human glycoprotein
thrombospondin-1 is a component of the extracellular matrix and is highly abundant in the …
Abstract
A successful colonization of different compartments of the human host requires multifactorial contacts between bacterial surface proteins and host factors. Extracellular matrix proteins and matricellular proteins such as thrombospondin-1 play a pivotal role as adhesive substrates to ensure a strong interaction with pathobionts like the Gram-positive Streptococcus pneumoniae and Staphylococcus aureus. The human glycoprotein thrombospondin-1 is a component of the extracellular matrix and is highly abundant in the bloodstream during bacteremia. Human platelets secrete thrombospondin-1, which is then acquired by invading pathogens to facilitate colonization and immune evasion. Gram-positive bacteria express a broad spectrum of surface-exposed proteins, some of which also recognize thrombospondin-1. This review highlights the importance of thrombospondin-1 as an adhesion substrate to facilitate colonization, and we summarize the variety of thrombospondin-1-binding proteins of S. pneumoniae and S. aureus.
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